Three-dimensional cell culture: the missing link in drug discovery
نویسندگان
چکیده
منابع مشابه
Three-dimensional cell culture: the missing link in drug discovery.
Cells, grown as monolayers (2D models), are routinely used as initial model systems for evaluating the effectiveness and safety of libraries of molecules with potential as therapeutic drugs. While this initial screening precedes preclinical animal studies before advancing to human clinical trials, cultured cells frequently determine the initial, yet crucial, 'stop/go' decisions on the progressi...
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ژورنال
عنوان ژورنال: Drug Discovery Today
سال: 2013
ISSN: 1359-6446
DOI: 10.1016/j.drudis.2012.10.003